{"id":11385611,"date":"2014-05-23T00:00:00","date_gmt":"2014-05-22T22:00:00","guid":{"rendered":"https:\/\/alertdiver.eu\/uncategorized-cs_cz\/nove-ucinky-kysliku-zjistene-diky-dan-europe-research\/"},"modified":"2014-05-23T00:00:00","modified_gmt":"2014-05-22T22:00:00","slug":"nove-ucinky-kysliku-zjistene-diky-dan-europe-research","status":"publish","type":"post","link":"https:\/\/alertdiver.eu\/cs_CZ\/clanky\/nove-ucinky-kysliku-zjistene-diky-dan-europe-research\/","title":{"rendered":"Nov\u00e9 \u00fa\u010dinky kysl\u00edku zji\u0161t\u011bn\u00e9 d\u00edky DAN Europe Research"},"content":{"rendered":"<p style=\"text-align: right;\"><em><br \/><\/em><\/p>\n<p style=\"text-align: justify;\">L\u00e9ka\u0159i a pot\u00e1p\u011b\u010dt\u00ed odborn\u00edci p\u016fsob\u00edc\u00ed v DAN Europe se pr\u016fb\u011b\u017en\u011b sna\u017e\u00ed dosahovat co nejlep\u0161\u00edch v\u00fdsledk\u016f v r\u00e1mci pot\u00e1p\u011b\u010dsk\u00e9 medic\u00edny a k tomuto \u00fa\u010delu tak\u00e9 prov\u00e1d\u011bj\u00ed \u010detn\u00e9 v\u011bdeck\u00e9 pokusy, kter\u00e9 by m\u011bly co nejv\u00edce prosp\u011bt cel\u00e9 pot\u00e1p\u011b\u010dsk\u00e9 ve\u0159ejnosti. Jedn\u00edm pravideln\u011b se opakuj\u00edc\u00edm p\u0159edm\u011btem v\u00fdzkumu je d\u00fdch\u00e1n\u00ed normobarick\u00e9ho kysl\u00edku a jeho kladn\u00fd \u00fa\u010dinek na lidsk\u00e9 zdrav\u00ed. D\u00fdch\u00e1n\u00ed 100% kysl\u00edku za atmosf\u00e9rick\u00e9ho tlaku zn\u00e1m\u00e9 jako normobarick\u00fd kysl\u00edk (NBO) se uk\u00e1zalo jako prosp\u011b\u0161n\u00e9 hned p\u0159i n\u011bkolika zdravotn\u00edch probl\u00e9mech, p\u0159i\u010dem\u017e mezi nejd\u016fle\u017eit\u011bj\u0161\u00ed aplikace pat\u0159\u00ed jeho nasazen\u00ed v p\u0159\u00edpad\u011b dekompresn\u00edho onemocn\u011bn\u00ed (DCS) &ndash; tato metoda v\u00fdznamn\u011b p\u0159isp\u00edv\u00e1 k rychlej\u0161\u00edmu vyt\u011bs\u0148ov\u00e1n\u00ed bublinek dus\u00edku z t\u011bla. Proto DAN Europe pova\u017euje d\u00fdch\u00e1n\u00ed NBO za jednozna\u010dn\u011b prvn\u00ed z\u00e1chrann\u00e9 opat\u0159en\u00ed, kter\u00e9 je nutno nasadit p\u0159i DSC. Nab\u00edz\u00ed se v\u0161ak ot\u00e1zka, zdali krom\u011b ji\u017e zn\u00e1m\u00fdch d\u016fvod\u016f pro d\u00fdch\u00e1n\u00ed normobarick\u00e9ho kysl\u00edku existuj\u00ed i n\u011bjak\u00e9 jin\u00e9 kladn\u00e9 \u00fa\u010dinky t\u00e9to metody. Tuto ot\u00e1zku si polo\u017eili n\u011bkte\u0159\u00ed v\u00fdzkumn\u00ed pracovn\u00ed DAN a rozhodli se prozkoumat dal\u0161\u00ed mo\u017en\u00e9 v\u00fdhody d\u00fdch\u00e1n\u00ed kysl\u00edku, a jak by se daly z\u00edskan\u00e9 v\u00fdsledky p\u0159ev\u00e9st do praktick\u00fdch a rad a doporu\u010den\u00ed pro dosa\u017een\u00ed v\u011bt\u0161\u00ed bezpe\u010dnosti p\u0159i pot\u00e1p\u011bn\u00ed.<\/p>\n<p style=\"text-align: justify;\">V p\u0159\u00edpad\u011b dekompresn\u00edho onemocn\u011bn\u00ed reaguje t\u011blo prakticky okam\u017eit\u011b tak, \u017ee b\u011bhem n\u011bkolika minut od dostaven\u00ed se DSC vznik\u00e1 cel\u00fd \u0159et\u011bzec z\u00e1n\u011btliv\u00fdch reakc\u00ed ve snaze br\u00e1nit se proti \u0161kodliv\u00fdm prvk\u016fm. B\u011bhem tohoto procesu se zachycuj\u00ed b\u00edlkoviny na povrchu tvo\u0159\u00edc\u00edch se bublinek dus\u00edku. Tyto bublinky pokryt\u00e9 b\u00edlkovinami jsou nejen stabiln\u011bj\u0161\u00ed, ale i men\u0161\u00ed ne\u017e jin\u00e9 obstruktivn\u00ed bublinky a to jim umo\u017e\u0148uje snadno cestovat krevn\u00edm ob\u011bhem. A kdy\u017e jsou b\u00edl\u00e9 krvinky vysl\u00e1ny do zan\u00edcen\u00fdch tk\u00e1n\u00ed, b\u00edlkovinami obalen\u00e9 bublinky mohou mezi nimi snadno proklouznout a dostat se do dal\u0161\u00edch t\u011blesn\u00fdch tk\u00e1n\u00ed. Nav\u00edc je zn\u00e1mo, \u017ee b\u00edlkoviny se mohou deformovat. To m\u016f\u017ee zp\u016fsobovat kumulaci kuli\u010dek voln\u00fdch tuk\u016f, co\u017e se u p\u0159\u00edpad\u016f dekompresn\u00edho onemocn\u011bn\u00ed st\u00e1v\u00e1 pom\u011brn\u011b \u010dasto a m\u016f\u017ee to zap\u0159i\u010dinit vznik tukov\u00e9 embolie, kter\u00e1 by mohla po\u0161kodit nervovou soustavu. Lidsk\u00fd organismus si v\u0161ak pro odstran\u011bn\u00ed t\u011bchto b\u00edlkovin z t\u011blesn\u00fdch tk\u00e1n\u00ed vytvo\u0159il jak\u00fdsi ochrann\u00fd mechanismus. B\u00edlkoviny zachycuje lymfatick\u00e1 soustava, kter\u00e1 je sou\u010d\u00e1st\u00ed cel\u00e9ho ob\u011bhu a sest\u00e1v\u00e1 z rozs\u00e1hl\u00e9 s\u00edt\u011b lymfatick\u00fdch c\u00e9v rozv\u00e1d\u011bj\u00edc\u00edch lymfu (m\u00edzu) do \u017eiln\u00ed soustavy. V\u00fdzkumem prov\u00e1d\u011bn\u00fdm v r\u00e1mci DAN a zam\u011b\u0159en\u00fdm na mo\u017enosti pou\u017eit\u00ed normobarick\u00e9ho kysl\u00edku se m\u011blo zjistit, zdali d\u00fdch\u00e1n\u00ed NBO posiluje lymfatickou aktivitu a tud\u00ed\u017e podporuje \u00fa\u010dinn\u011bj\u0161\u00ed eliminaci b\u00edlkovin. Zm\u00edn\u011bn\u00fd v\u00fdzkum organizovala v\u00fdzkumn\u00e1 sekce DAN Europe Research ve spolupr\u00e1ci s Universit\u00e9 Libre de Bruxelles, Haute Ecole Paul Henri Spaak a Vojensk\u00e9 nemocnice kr\u00e1lovny Astrid v Bruselu. C\u00edl v\u00fdzkumu byl jednozna\u010dn\u00fd: Anal\u00fdza p\u0159\u00edzniv\u00fdch \u00fa\u010dink\u016f d\u00fdch\u00e1n\u00ed kysl\u00edku na zachycov\u00e1n\u00ed b\u00edlkovin. Vych\u00e1zelo se z p\u0159edpokladu, \u017ee kysl\u00edk p\u016fsob\u00ed kladn\u011b na metabolismus lymfatick\u00fdch c\u00e9v a tak\u00e9 redukuje hromad\u011bn\u00ed tekutin v t\u011blesn\u00fdch tk\u00e1n\u00edch (otoky).<\/p>\n<p style=\"text-align: justify;\">V\u00fdzkumu se z\u00fa\u010dastnilo 7 zdrav\u00fdch dobrovoln\u00edk\u016f ve v\u011bku 19 a\u017e 27 let. Osoby trp\u00edc\u00ed diabetem, n\u011bjak\u00fdm c\u00e9vn\u00edm onemocn\u011bn\u00edm nebo po \u00farazu horn\u00ed kon\u010detiny byly z pokus\u016f vylou\u010deny a tot\u00e9\u017e platilo pro t\u011bhotn\u00e9 \u017eeny a aktivn\u00ed sportovce zab\u00fdvaj\u00edc\u00ed se druhem sportu, kter\u00fd by mohl v lymfatick\u00e9 soustav\u011b zp\u016fsobovat n\u011bjak\u00e9 abnormality (hr\u00e1\u010di volejbalu, vyznava\u010di bojov\u00fdch um\u011bn\u00ed atd.). Testovan\u00e9 osoby byly vy\u0161et\u0159eny izotopickou metodou ihned po injek\u010dn\u00edm p\u0159ijet\u00ed soln\u00e9ho p\u0159\u00edpravku obsahuj\u00edc\u00edho ozna\u010den\u00e9 b\u00edlkoviny. Injek\u010dn\u011b aplikovan\u00e9 b\u00edlkoviny se li\u0161ily mno\u017estv\u00edm v rozmez\u00ed od 50 do 100 nm, aby je lymfatick\u00e1 soustava dob\u0159e absorbovala. Injekce zp\u016fsobila m\u00edrn\u00e9 nahromad\u011bn\u00ed tekutiny t\u011bsn\u011b pod povrchem poko\u017eky na h\u0159betu ruky. Injektovan\u00e9 b\u00edlkoviny nejd\u0159\u00edv\u011b absorbovaly bu\u0148ky a pot\u00e9 se dostaly do lymfatick\u00e9 soustavy. B\u011bhem pokus\u016f testovan\u00e9 osoby le\u017eely nebo se o n\u011bco op\u00edraly. Prvn\u00ed pokus byl zam\u011b\u0159en na anal\u00fdzu absorpce b\u00edlkovin do lymfatick\u00fdch uzlin, kdy\u017e v\u0161ech sedm dobrovol\u00edk\u016f d\u00fdchalo norm\u00e1ln\u00ed okoln\u00ed vzduch. B\u011bhem druh\u00e9ho pokusu byly pokusn\u00e9 osoby po\u017e\u00e1d\u00e1ny, aby d\u00fdchaly normobarick\u00fd kysl\u00edk pomoc\u00ed obli\u010dejov\u00e9 masky zakr\u00fdvaj\u00edc\u00ed nos i \u00fasta. Ihned po injek\u010dn\u00ed aplikaci b\u00edlkovin a za pr\u016fb\u011b\u017en\u00e9ho d\u00fdch\u00e1n\u00ed kysl\u00edku po dobu t\u0159iceti minut se m\u011b\u0159ila izotopick\u00e1 aktivita lymfatick\u00fdch uzlin pomoc\u00ed gamakamery, aby se zjistila rychlost zachycov\u00e1n\u00ed b\u00edlkovin a tak\u00e9 mno\u017estv\u00ed b\u00edlkovin vylou\u010den\u00fdch lymfatickou soustavou. Z\u00e1rove\u0148 se m\u011b\u0159il tlak kysl\u00edku v t\u00e9 oblasti pod poko\u017ekou, kde se hromadila tekutina.<\/p>\n<p style=\"text-align: justify;\">U v\u0161ech sedmi subjekt\u016f byl po t\u0159icetiminutov\u00e9m d\u00fdch\u00e1n\u00ed normobarick\u00e9ho kysl\u00edku nam\u011b\u0159en n\u00e1r\u016fst izotopick\u00e9 aktivity v bu\u0148k\u00e1ch v oblasti podpa\u017ed\u00ed. Nav\u00edc byl b\u011bhem prvn\u00edch deseti minut d\u00fdch\u00e1n\u00ed kysl\u00edku zaznamen\u00e1n n\u00e1r\u016fst tlaku kysl\u00edku v oblasti hromad\u011bn\u00ed tekutin (otok). Po prvn\u00edm n\u00e1r\u016fstu tlaku kysl\u00edku se v\u0161ak jeho vy\u0161\u0161\u00ed \u00farove\u0148 ust\u00e1lila na tzv. f\u00e1zi plateau (na zv\u00fd\u0161en\u00e9m stavu). Po ukon\u010den\u00ed d\u00fdch\u00e1n\u00ed kysl\u00edku klesly hodnoty rychle zp\u011bt na stejn\u00e9 \u00farovn\u011b tlaku, kter\u00e9 byly nam\u011b\u0159eny p\u0159ed d\u00fdch\u00e1n\u00edm NBO. Rychlost a mno\u017estv\u00ed eliminace b\u00edlkovin lymfatickou soustavou b\u011bhem d\u00fdch\u00e1n\u00ed kysl\u00edku se porovnaly s eliminac\u00ed b\u00edlkovin p\u0159i d\u00fdch\u00e1n\u00ed norm\u00e1ln\u00edho okoln\u00edho vzduchu. V\u00fdsledky srovn\u00e1n\u00ed uk\u00e1zaly, \u017ee mno\u017estv\u00ed a rychlost absorpce zachycen\u00fdch b\u00edlkovin byly v\u00fdznamn\u011b vy\u0161\u0161\u00ed po 30 minut\u00e1ch d\u00fdch\u00e1n\u00ed 100% normobarick\u00e9ho kysl\u00edku. D\u00fdch\u00e1n\u00ed kysl\u00edku u v\u0161ech dobrovoln\u00edk\u016f v\u00fdrazn\u011b zlep\u0161ilo metabolismus lymfatick\u00e9 soustavy a zachycov\u00e1n\u00ed b\u00edlkovin v lymfatick\u00fdch c\u00e9v\u00e1ch <em>(viz. obr\u00e1zek, se srovn\u00e1n\u00ed mezi krevn\u00edm syst\u00e9mu a lymfatick\u00e9ho syst\u00e9mu, p\u0159ed a po l\u00e9\u010db\u011b).<\/em> Nav\u00edc k t\u011bmto p\u0159\u00edzniv\u00fdm \u00fa\u010dink\u016fm na ostra\u0148ov\u00e1n\u00ed b\u00edlkovin se p\u0159i pokusech prok\u00e1zalo, \u017ee d\u00fdch\u00e1n\u00ed kysl\u00edku lze pou\u017e\u00edt i p\u0159i l\u00e9\u010db\u011b otok\u016f. Z\u00e1v\u011bry vyvozen\u00e9 DAN Europe ze shora uveden\u00e9ho v\u00fdzkumu jsou jednozna\u010dn\u00e9: Po pot\u00e1p\u011b\u010dsk\u00e9 nehod\u011b se v\u0161em pot\u00e1p\u011b\u010d\u016fm doporu\u010duje okam\u017eit\u011b nasadit d\u00fdch\u00e1n\u00ed kysl\u00edku po dobu alespo\u0148 t\u0159iceti minut jako prvn\u00ed pomoc p\u0159\u00edmo na m\u00edst\u011b. Spr\u00e1vn\u00e1 prvn\u00ed pomoc po nehod\u011b je pro n\u00e1slednou terapii z\u00e1sadn\u011b d\u016fle\u017eit\u00e1 a posl\u00e1n\u00edm v\u00fdzkumn\u00e9 sekce DAN je analyzovat v\u0161echny mo\u017en\u00e9 prvky pot\u0159ebn\u00e9 pro \u00fa\u010dinnou l\u00e9ka\u0159skou p\u00e9\u010di, kterou pot\u0159ebujete a kterou si zasluhujete.<\/p>\n<p style=\"text-align: justify;\">&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>L\u00e9ka\u0159i a pot\u00e1p\u011b\u010dt\u00ed odborn\u00edci p\u016fsob\u00edc\u00ed v DAN Europe se pr\u016fb\u011b\u017en\u011b sna\u017e\u00ed dosahovat co nejlep\u0161\u00edch v\u00fdsledk\u016f v r\u00e1mci pot\u00e1p\u011b\u010dsk\u00e9 medic\u00edny a k tomuto \u00fa\u010delu tak\u00e9 prov\u00e1d\u011bj\u00ed&#8230;<\/p>\n","protected":false},"author":1,"featured_media":11374972,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[384],"tags":[],"authors":[1233],"class_list":["post-11385611","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-clanky","authors-jolien-spoormans-cs_cz"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v24.2 - 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